Version 5.4
Homo sapiens Gene: KCNJ15
Summary
InnateDB Gene IDBG-3255.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ15
Gene Name potassium inwardly-rectifying channel, subfamily J, member 15
Synonyms IRKK; KIR1.3; KIR4.2
Species Homo sapiens
Ensembl Gene ENSG00000157551
Encoded Proteins
IDBP-3257
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231884
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231886
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231888
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231890
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231892
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231894
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-231896
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-365669
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-365670
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-365683
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-365705
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-597895
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-588942
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-585698
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-585459
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-587513
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-590392
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-586769
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-811159
potassium inwardly-rectifying channel, subfamily J, member 15
IDBP-811160
potassium inwardly-rectifying channel, subfamily J, member 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:38157034-38307357
Strand Forward strand
Band q22.13
Transcripts
ENST00000328656 ENSP00000331698
ENST00000398938 ENSP00000381911
ENST00000398934 ENSP00000381907
ENST00000398932 ENSP00000381905
ENST00000398930 ENSP00000381904
ENST00000398928 ENSP00000381902
ENST00000398927 ENSP00000381901
ENST00000398925 ENSP00000381899
ENST00000443341 ENSP00000413013
ENST00000417042 ENSP00000392951
ENST00000438657 ENSP00000414487
ENST00000419868 ENSP00000400849
ENST00000549158 ENSP00000449140
ENST00000549805 ENSP00000448770
ENST00000547341 ENSP00000447111
ENST00000549932 ENSP00000448676
ENST00000547595 ENSP00000450254
ENST00000548700 ENSP00000448886
ENST00000551422 ENSP00000449419
ENST00000612702 ENSP00000484960
ENST00000613499 ENSP00000479100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062609
View Gene Order
ENSBTAG00000000973
Not yet available
Pathways
NETPATH
REACTOME
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.411299 Hs.609253
RefSeq NM_001276435 NM_001276436 NM_001276437 NM_001276438 NM_001276439 NM_002243 NM_170736 NM_170737 XM_005260975 XM_005260976
HUGO
OMIM
CCDS CCDS13656
HPRD 03659
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca