Version 5.4
Homo sapiens Gene: NLRC5
Summary
InnateDB Gene IDBG-32729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRC5
Gene Name NLR family, CARD domain containing 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140853
Encoded Proteins
IDBP-32733
NLR family, CARD domain containing 5
IDBP-591463
NLR family, CARD domain containing 5
IDBP-377641
NLR family, CARD domain containing 5
IDBP-601934
NLR family, CARD domain containing 5
IDBP-592505
NLR family, CARD domain containing 5
IDBP-587385
NLR family, CARD domain containing 5
IDBP-595605
NLR family, CARD domain containing 5
IDBP-601958
NLR family, CARD domain containing 5
IDBP-603434
NLR family, CARD domain containing 5
IDBP-594722
NLR family, CARD domain containing 5
IDBP-590515
NLR family, CARD domain containing 5
IDBP-602349
NLR family, CARD domain containing 5
IDBP-603163
NLR family, CARD domain containing 5
IDBP-598515
NLR family, CARD domain containing 5
IDBP-604031
NLR family, CARD domain containing 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19414032
NLRC5 is nn NLR (nucleotide-binding domain and leucine-rich repeat containing family receptors) that is part of the family of pattern recognition receptors (PRRs) and is involved in immunity against intracellular pathogens.
PMID 20061403
NLRC5 represents a molecular switch of IFN-gamma activation sequence/IFN-specific response element signalling pathways contributing to antiviral defence mechanisms.
PMID 20434986
NLRC5 is a negative regulator that blocks two central components of the NF-kappaB and type I interferon signalling pathways and has an important role in homeostatic control of innate immunity.
PMID 21148033
NLRC5 is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions. (Demonstrated in murine model)
PMID 26620909
The reversible ubiquitin editing of NLRC5 determines NLRC5â?? IKBKB interaction dynamics and plays a crucial role in precisely regulating NFκB signalling
Entrez Gene
Summary This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56989485-57083531
Strand Forward strand
Band q13
Transcripts
ENST00000262510 ENSP00000262510
ENST00000399221 ENSP00000440184
ENST00000436936 ENSP00000389739
ENST00000539881 ENSP00000441679
ENST00000543141
ENST00000538273
ENST00000535658
ENST00000544641 ENSP00000439464
ENST00000538059 ENSP00000441311
ENST00000539144 ENSP00000441727
ENST00000538805 ENSP00000442906
ENST00000545081 ENSP00000443825
ENST00000538110 ENSP00000441597
ENST00000536231
ENST00000543030 ENSP00000440153
ENST00000538453 ENSP00000444773
ENST00000540182 ENSP00000438548
ENST00000538930
ENST00000538778
ENST00000541020
ENST00000537056 ENSP00000437583
ENST00000534931
ENST00000535284
ENST00000543402
ENST00000545349 ENSP00000444960
ENST00000544189
ENST00000534927
ENST00000543103
ENST00000543049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0043549 regulation of kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.528836 Hs.708775
RefSeq NM_032206 XM_005256193 XM_005256194 XM_005256195 XM_005256197 XM_005256199 XM_005256200 XM_006721297 XM_006721300
HUGO
OMIM
CCDS CCDS10773
HPRD 14831
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca