InnateDB Protein
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IDBP-601934.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NLRC5
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Protein Name
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NLR family, CARD domain containing 5
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441679
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InnateDB Gene
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IDBG-32729 (NLRC5)
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Protein Structure
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Function |
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269PubMed:20061403, ECO:0000269PubMed:20434986}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:20061403, ECO:0000269PubMed:20434986}.
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Disease Associations |
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Tissue Specificity |
Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate. {ECO:0000269PubMed:20061403, ECO:0000269PubMed:20434986}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0032088
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negative regulation of NF-kappaB transcription factor activity
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GO:0032480
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negative regulation of type I interferon production
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GO:0043549
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regulation of kinase activity
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GO:0045087
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innate immune response (InnateDB)
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GO:0045345
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positive regulation of MHC class I biosynthetic process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0051607
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defense response to virus
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GO:0060335
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positive regulation of interferon-gamma-mediated signaling pathway
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GO:0060339
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negative regulation of type I interferon-mediated signaling pathway
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GO:0060340
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positive regulation of type I interferon-mediated signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR007111
NACHT nucleoside triphosphatase
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86WI3
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PhosphoSite |
PhosphoSite-Q86WI3
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TrEMBL |
F5H274
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UniProt Splice Variant |
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Entrez Gene |
84166
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UniGene |
Hs.708775
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RefSeq |
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HUGO |
HGNC:29933
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OMIM |
613537
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CCDS |
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HPRD |
14831
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IMGT |
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EMBL |
AC009090
AC023825
AF389420
AK027414
AK027416
AK074133
AK074182
AK090439
BC050527
BC063566
EF452236
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GenPept |
AAH50527
AAH63566
AAO59377
ABO40479
BAB55096
BAB55098
BAB84959
BAB85008
BAC03420
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