Homo sapiens Gene: MYH7

Summary
InnateDB Gene IDBG-3295.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol MYH7
Gene Name myosin, heavy chain 7, cardiac muscle, beta
Synonyms CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM
Species Homo sapiens
Ensembl Gene ENSG00000092054
Encoded Proteins
IDBP-3299 myosin, heavy chain 7, cardiac muscle, beta
Entrez Gene
Summary Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14: 23881947-23904927
Strand Reverse strand
Band q11.2
Transcripts
ENST00000355349  ENSP00000347507
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein‑Protein  6
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008307 structural constituent of muscle
GO:0016887 ATPase activity
GO:0030898 actin-dependent ATPase activity
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000302 response to reactive oxygen species
GO:0002027 regulation of heart rate
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0007512 adult heart development
GO:0030049 muscle filament sliding
GO:0055010 ventricular cardiac muscle tissue morphogenesis
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005859 muscle myosin complex
GO:0005925 focal adhesion
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0032982 myosin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000053093 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000009703 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
hsa04260  Cardiac muscle contraction
hsa05414  Dilated cardiomyopathy
hsa05410  Hypertrophic cardiomyopathy (HCM)
hsa04530  Tight junction
hsa05416  Viral myocarditis
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P12883 
TrEMBL A6N930 A6N931 A8CLL2 A8CLN2 Q59EV3
UniProt Splice Variant
Entrez Gene 4625 
UniGene Hs.655129 Hs.719946 Hs.733442
RefSeq NM_000257 
HUGO 7577 
OMIM 160760
CCDS CCDS9601 
HPRD 01175
IMGT
EMBL AB209708 AJ238393 BC112171 BC112173 CH471078 EF179180 EF630363 EF630364 EF630365 EF630367 EU091312 EU091313 EU091314 EU091315 EU091316 EU747717 M17712 M21665 M25133 M25134 M25135 M27636 M57965 M58018 X03741 X04627 X04628 X04629 X04630 X04631 X04632 X04633 X05631 X06976 X51591 X52889
GenPept AAA36343  AAA36345  AAA51837  AAA60384  AAA62830  AAA79019  AAI12172  AAI12174  ABN05283  ABR18776  ABR18777  ABR18778  ABR18780  ABV44799  ABV44800  ABV44801  ABV44802  ABV44803  ACH92815  BAD92945  CAA27381  CAA28300  CAA29119  CAA30039  CAA35940  CAA37068  CAC20413  EAW66152 
ImmGen MYH7 (murine) 
RNA Seq Atlas 4625