InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYH7

Summary

InnateDB Gene

IDBG-3295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH7

Gene Name

myosin, heavy chain 7, cardiac muscle, beta

Synonyms

CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM

Species

Homo sapiens

Ensembl Gene

ENSG00000092054

Encoded Proteins

IDBP-3299

myosin, heavy chain 7, cardiac muscle, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:23412738-23435718

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000355349

ENSP00000347507

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0002027	regulation of heart rate
GO:0006200	ATP catabolic process
GO:0006936	muscle contraction
GO:0006941	striated muscle contraction
GO:0007512	adult heart development
GO:0030049	muscle filament sliding
GO:0055010	ventricular cardiac muscle tissue morphogenesis

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005859	muscle myosin complex
GO:0005925	focal adhesion
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0032982	myosin filament

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000053093

View Gene Order

ENSBTAG00000009703

Not yet available

Pathways

NETPATH

REACTOME

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04530

Tight junction pathway

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa04260

Cardiac muscle contraction pathway

hsa05414

Dilated cardiomyopathy pathway

hsa05416

Viral myocarditis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.655129 Hs.719946 Hs.733442

RefSeq

NM_000257 XM_005267696 XM_005267697

HUGO

OMIM

CCDS

CCDS9601

HPRD

01175

IMGT

EMBL

GenPept

RNA Seq Atlas