Homo sapiens Gene: MYH7
Summary
InnateDB Gene IDBG-3295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYH7
Gene Name myosin, heavy chain 7, cardiac muscle, beta
Synonyms CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM;
Species Homo sapiens
Ensembl Gene ENSG00000092054
Encoded Proteins
myosin, heavy chain 7, cardiac muscle, beta
Protein Structure
Entrez Gene
Summary Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23412738-23435718
Strand Reverse strand
Band q11.2
Transcripts
ENST00000355349 ENSP00000347507
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0030898 actin-dependent ATPase activity
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002027 regulation of heart rate
GO:0006200 ATP catabolic process
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007512 adult heart development
GO:0030049 muscle filament sliding
GO:0055010 ventricular cardiac muscle tissue morphogenesis
Cellular Component
GO:0001725 stress fiber
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005859 muscle myosin complex
GO:0005925 focal adhesion
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0032982 myosin filament
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Translocation of GLUT4 to the plasma membrane pathway
Membrane Trafficking pathway
KEGG
Cardiac muscle contraction pathway
Tight junction pathway
Hypertrophic cardiomyopathy (HCM) pathway
Dilated cardiomyopathy pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P12883
TrEMBL A6N930 A6N931 A8CLL2 A8CLN2 L0L5E6 Q59EV3
UniProt Splice Variant
Entrez Gene 4625
UniGene Hs.655129 Hs.719946 Hs.733442
RefSeq NM_000257 XM_005267696 XM_005267697
HUGO HGNC:7577
OMIM 160760
CCDS CCDS9601
HPRD 01175
IMGT
EMBL AB209708 AJ238393 BC112171 BC112173 CH471078 EF179180 EF630363 EF630364 EF630365 EF630367 EU091312 EU091313 EU091314 EU091315 EU091316 EU747717 JX504729 JX504730 JX504731 JX504732 JX504733 JX504734 JX504735 JX504736 JX504737 JX504738 JX504739 JX504740 JX504741 JX504742 JX504743 JX504744 JX504745 JX504746 JX504747 JX504748 JX504749 JX504750 JX504751 JX504752 JX504753 JX504754 JX504755 JX504756 JX504757 JX504758 JX504759 JX504760 JX504761 JX504762 JX504763 JX504764 JX504765 JX504766 JX504767 JX504768 JX504769 JX504770 JX504771 JX504772 JX504773 JX504774 JX504775 JX504776 JX504777 JX504778 JX504779 JX504780 JX504782 JX504783 JX504784 JX504785 JX504786 JX504787 JX504788 JX504789 JX504790 JX504791 JX504792 JX504793 JX504794 JX504795 JX504796 JX504797 JX504798 JX504799 JX504800 JX504801 JX504802 JX504803 JX976588 JX976589 JX976590 JX976591 JX976592 JX976593 JX976594 JX976595 JX976596 JX976597 JX976598 JX976601 JX976602 JX976603 JX976604 JX976605 JX976606 JX976607 JX976608 M17712 M21665 M25133 M25134 M25135 M27636 M57965 M58018 X03741 X04627 X04628 X04629 X04630 X04631 X04632 X04633 X05631 X06976 X51591 X52889
GenPept AAA36343 AAA36345 AAA51837 AAA60384 AAA62830 AAA79019 AAI12172 AAI12174 ABN05283 ABR18776 ABR18777 ABR18778 ABR18780 ABV44799 ABV44800 ABV44801 ABV44802 ABV44803 ACH92815 AGB51777 AGB51778 AGB51779 AGB51780 AGB51781 AGB51782 AGB51783 AGB51784 AGB51785 AGB51786 AGB51787 AGB51788 AGB51789 AGB51790 AGB51791 AGB51792 AGB51793 AGB51794 AGB51795 AGB51796 AGB51797 AGB51798 AGB51799 AGB51800 AGB51801 AGB51802 AGB51803 AGB51804 AGB51805 AGB51806 AGB51807 AGB51808 AGB51809 AGB51810 AGB51811 AGB51812 AGB51813 AGB51814 AGB51815 AGB51816 AGB51817 AGB51818 AGB51819 AGB51820 AGB51821 AGB51822 AGB51823 AGB51824 AGB51825 AGB51826 AGB51827 AGB51828 AGB51830 AGB51831 AGB51832 AGB51833 AGB51834 AGB51835 AGB51836 AGB51837 AGB51838 AGB51839 AGB51840 AGB51841 AGB51842 AGB51843 AGB51844 AGB51845 AGB51846 AGB51847 AGB51848 AGB51849 AGB51850 AGB51851 AGS36280 AGS36281 AGS36282 AGS36283 AGS36284 AGS36285 AGS36286 AGS36287 AGS36288 AGS36289 AGS36290 AGS36293 AGS36294 AGS36295 AGS36296 AGS36297 AGS36298 AGS36299 AGS36300 BAD92945 CAA27381 CAA28300 CAA29119 CAA30039 CAA35940 CAA37068 CAC20413 EAW66152
ImmGen MYH7 (murine)
RNA Seq Atlas 4625