Version 5.4
Homo sapiens Gene: UCN2
Summary
InnateDB Gene IDBG-33074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCN2
Gene Name urocortin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145040
Encoded Proteins
IDBP-33076
urocortin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48561727-48563773
Strand Reverse strand
Band p21.31
Transcripts
ENST00000273610 ENSP00000273610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0042562 hormone binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding
Biological Process
GO:0006171 cAMP biosynthetic process
GO:0006950 response to stress
GO:0007586 digestion
GO:0008283 cell proliferation
GO:0010629 negative regulation of gene expression
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035902 response to immobilization stress
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000049699
View Gene Order
Cross-References
SwissProt Q96RP3
TrEMBL
UniProt Splice Variant
Entrez Gene 90226
UniGene Hs.631914
RefSeq NM_033199
HUGO HGNC:18414
OMIM 605902
CCDS CCDS2772
HPRD
IMGT
EMBL AF320560 BC002647 BC022096
GenPept AAH02647 AAH22096 AAK52672
RNA Seq Atlas 90226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca