InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCN2

Summary

InnateDB Protein

IDBP-33076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCN2

Protein Name

urocortin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000273610

InnateDB Gene

IDBG-33074 (UCN2)

Protein Structure

UniProt Annotation

Function

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0042562	hormone binding
GO:0051431	corticotropin-releasing hormone receptor 2 binding

Biological Process

GO:0006171	cAMP biosynthetic process
GO:0006950	response to stress
GO:0007586	digestion
GO:0008283	cell proliferation
GO:0010629	negative regulation of gene expression
GO:0033685	negative regulation of luteinizing hormone secretion
GO:0035902	response to immobilization stress
GO:0046882	negative regulation of follicle-stimulating hormone secretion
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071456	cellular response to hypoxia