Version 5.4
Homo sapiens Gene: NPNT
Summary
InnateDB Gene IDBG-33102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPNT
Gene Name nephronectin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168743
Encoded Proteins
IDBP-33104
nephronectin
IDBP-33106
nephronectin
IDBP-375466
nephronectin
IDBP-375468
nephronectin
IDBP-476995
nephronectin
IDBP-484567
nephronectin
IDBP-475669
nephronectin
IDBP-474188
nephronectin
IDBP-476157
nephronectin
IDBP-474812
nephronectin
IDBP-478732
nephronectin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:105894775-106004027
Strand Forward strand
Band q24
Transcripts
ENST00000379987 ENSP00000369323
ENST00000305572 ENSP00000302557
ENST00000427316 ENSP00000389252
ENST00000453617 ENSP00000402884
ENST00000504304 ENSP00000426951
ENST00000514622 ENSP00000422044
ENST00000506666 ENSP00000422474
ENST00000503451 ENSP00000426146
ENST00000514837 ENSP00000427507
ENST00000513430
ENST00000506056
ENST00000511518
ENST00000505821
ENST00000514632
ENST00000504787 ENSP00000421480
ENST00000505917 ENSP00000426219
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0007160 cell-matrix adhesion
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033631 cell-cell adhesion mediated by integrin
GO:0045184 establishment of protein localization
GO:0045669 positive regulation of osteoblast differentiation
GO:0045987 positive regulation of smooth muscle contraction
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071356 cellular response to tumor necrosis factor
GO:0097195 pilomotor reflex
GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0016020 membrane
GO:0030485 smooth muscle contractile fiber
GO:0031012 extracellular matrix
GO:0034678 alpha8-beta1 integrin complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040998
View Gene Order
ENSBTAG00000006686
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.612931 Hs.623485
RefSeq NM_001033047 NM_001184690 NM_001184691 NM_001184692 NM_001184693 XM_005262890 XM_006714171
HUGO
OMIM
CCDS CCDS34046 CCDS54784 CCDS54785 CCDS54786 CCDS54787
HPRD 14141
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca