InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPNT

Summary

InnateDB Protein

IDBP-33104.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPNT

Protein Name

nephronectin

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369323

InnateDB Gene

IDBG-33102 (NPNT)

Protein Structure

UniProt Annotation

Function

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Trapped on the cell surface or in the extracellular matrix. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels. {ECO:0000269PubMed:15754038}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0007160	cell-matrix adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization
GO:0033631	cell-cell adhesion mediated by integrin
GO:0045669	positive regulation of osteoblast differentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071356	cellular response to tumor necrosis factor

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001881 EGF-like calcium-binding domain
IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF07645
PF01826

PRINTS

PR00020

PIRSF

SMART

SM00181
SM00137
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt