InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GIPC1

Summary

InnateDB Gene

IDBG-33390.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GIPC1

Gene Name

GIPC PDZ domain containing family, member 1

Synonyms

C19orf3; GIPC; GLUT1CBP; Hs.6454; IIP-1; NIP; RGS19IP1; SEMCAP; SYNECTIIN; SYNECTIN; TIP-2

Species

Homo sapiens

Ensembl Gene

ENSG00000123159

Encoded Proteins

IDBP-33392

GIPC PDZ domain containing family, member 1

IDBP-244433

GIPC PDZ domain containing family, member 1

IDBP-244439

GIPC PDZ domain containing family, member 1

IDBP-765403

IDBP-762768

IDBP-762479

IDBP-760934

IDBP-761752

IDBP-761401

IDBP-765501

IDBP-762962

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:14477760-14496149

Strand

Reverse strand

Band

p13.12

Transcripts

ENST00000345425	ENSP00000340698
ENST00000393033	ENSP00000376753
ENST00000393028	ENSP00000376748
ENST00000587969	ENSP00000464879
ENST00000591349	ENSP00000467077
ENST00000587934	ENSP00000466624
ENST00000591245	ENSP00000466105
ENST00000589631	ENSP00000466312
ENST00000589497	ENSP00000465003
ENST00000587210	ENSP00000468787
ENST00000585606
ENST00000587811
ENST00000586027	ENSP00000466747

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	51 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0030165	PDZ domain binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006605	protein targeting
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007268	synaptic transmission
GO:0014047	glutamate secretion
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031647	regulation of protein stability
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032467	positive regulation of cytokinesis
GO:0043542	endothelial cell migration
GO:0048167	regulation of synaptic plasticity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005903	brush border
GO:0005938	cell cortex
GO:0008021	synaptic vesicle
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030139	endocytic vesicle
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019433

View Gene Order

ENSBTAG00000000764

Not yet available

Pathways

NETPATH

NetPath_7

TGF_beta_Receptor pathway

REACTOME

KEGG

INOH

PID NCI

trkrpathway

Neurotrophic factor-mediated Trk receptor signaling

syndecan_4_pathway

Syndecan-4-mediated signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.655012

RefSeq

NM_005716 NM_202468 NM_202469 NM_202470 NM_202494

HUGO

OMIM

CCDS

CCDS12310 CCDS12311

HPRD

05462

IMGT

EMBL

GenPept

RNA Seq Atlas