Homo sapiens Gene: GALNT6 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-33414.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GALNT6 | ||||||||||||||||||
Gene Name | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) | ||||||||||||||||||
Synonyms | GALNAC-T6; GalNAcT6 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000139629 | ||||||||||||||||||
Encoded Proteins |
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
polypeptide N-acetylgalactosaminyltransferase 6
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 12:51351247-51392867 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q13.13 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
O-linked glycosylation of mucins pathway
Post-translational protein modification pathway
O-linked glycosylation pathway
Metabolism of proteins pathway
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KEGG |
Mucin type O-Glycan biosynthesis pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | S4R310 S4R345 S4R355 S4R370 S4R396 S4R3L4 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 11226 | ||||||||||||||||||
UniGene | |||||||||||||||||||
RefSeq | NM_007210 XM_005268607 XM_005268608 XM_006719214 | ||||||||||||||||||
HUGO | HGNC:4128 | ||||||||||||||||||
OMIM | 605148 | ||||||||||||||||||
CCDS | CCDS8813 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC046135 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 11226 | ||||||||||||||||||