InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SH2B2

Summary

InnateDB Gene

IDBG-33504.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2B2

Gene Name

SH2B adaptor protein 2

Synonyms

APS

Species

Homo sapiens

Ensembl Gene

ENSG00000160999

Encoded Proteins

IDBP-384313

SH2B adaptor protein 2

IDBP-598721

SH2B adaptor protein 2

IDBP-810884

SH2B adaptor protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt\'s lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102285091-102321711

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000444095	ENSP00000401883
ENST00000536178	ENSP00000440273
ENST00000617975	ENSP00000483034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008269	JAK pathway signal transduction adaptor activity
GO:0042802	identical protein binding

Biological Process

GO:0001922	B-1 B cell homeostasis
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0019222	regulation of metabolic process
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0046425	regulation of JAK-STAT cascade
GO:0046578	regulation of Ras protein signal transduction
GO:0050776	regulation of immune response
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050873	brown fat cell differentiation