InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SH2B2

Summary

InnateDB Gene

IDBG-640272.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2B2

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009691

Encoded Proteins

IDBP-692513

SH2B adaptor protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160999:
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt\'s lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:35192687-35204610

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000012781

ENSBTAP00000012781

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008269	JAK pathway signal transduction adaptor activity

Biological Process

GO:0001922	B-1 B cell homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0019222	regulation of metabolic process
GO:0030036	actin cytoskeleton organization
GO:0035556	intracellular signal transduction
GO:0046425	regulation of JAK-STAT cascade
GO:0050776	regulation of immune response
GO:0050851	antigen receptor-mediated signaling pathway
GO:0050873	brown fat cell differentiation