InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POLR2J

Summary

InnateDB Gene

IDBG-33638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2J

Gene Name

polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa

Synonyms

hRPB14; POLR2J1; RPB11; RPB11A; RPB11m

Species

Homo sapiens

Ensembl Gene

ENSG00000005075

Encoded Proteins

IDBP-33642

polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa

IDBP-242898

polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102473118-102478907

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000292614	ENSP00000292614
ENST00000393794	ENSP00000377383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001055	RNA polymerase II activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0005515	protein binding
GO:0030275	LRR domain binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039771

View Gene Order

ENSBTAG00000005446

Not yet available

Pathways

NETPATH

REACTOME

REACT_6344

Tat-mediated HIV elongation arrest and recovery pathway

REACT_6143

Pausing and recovery of Tat-mediated HIV elongation pathway

REACT_6354

Viral Messenger RNA Synthesis pathway

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1470

mRNA Capping pathway

REACT_12417

MicroRNA (miRNA) biogenesis pathway

REACT_1655

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway

REACT_22107

RNA Polymerase II Pre-transcription Events pathway

REACT_1845

Formation of RNA Pol II elongation complex pathway

REACT_846

Formation of the Early Elongation Complex pathway

REACT_833

RNA Polymerase II Transcription Elongation pathway

REACT_2089

RNA Polymerase II Promoter Escape pathway

REACT_1851

RNA Polymerase II Transcription Initiation pathway

REACT_834

RNA Polymerase II Transcription Initiation And Promoter Clearance pathway

REACT_975

RNA Pol II CTD phosphorylation and interaction with CE pathway

REACT_22201

Formation of HIV elongation complex in the absence of HIV Tat pathway

REACT_6332

HIV Transcription Initiation pathway

REACT_6244

Pausing and recovery of HIV elongation pathway

REACT_6253

RNA Polymerase II HIV Promoter Escape pathway

REACT_6319

Formation of the HIV-1 Early Elongation Complex pathway

REACT_6346

Formation of HIV-1 elongation complex containing HIV-1 Tat pathway

REACT_6162

Tat-mediated elongation of the HIV-1 transcript pathway

REACT_6261

Abortive elongation of HIV-1 transcript in the absence of Tat pathway

REACT_6237

RNA Pol II CTD phosphorylation and interaction with CE pathway

REACT_6259

HIV elongation arrest and recovery pathway

REACT_6233

Transcription of the HIV genome pathway

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_1941

Formation of transcription-coupled NER (TC-NER) repair complex pathway

REACT_2222

Dual incision reaction in TC-NER pathway

REACT_1628

Transcription-coupled NER (TC-NER) pathway

REACT_6167

Influenza Infection pathway

REACT_267668

Transcriptional regulation by small RNAs pathway

REACT_6152

Influenza Viral RNA Transcription and Replication pathway

REACT_6274

HIV Transcription Elongation pathway

REACT_1366

RNA Polymerase II Transcription pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6145

Influenza Life Cycle pathway

REACT_1735

mRNA Splicing pathway

REACT_1826

Nucleotide Excision Repair pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_216

DNA Repair pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

hsa03020

RNA polymerase pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

5439

UniGene

RefSeq

XM_005250452 NM_006234

HUGO

HGNC:9197

OMIM

604150

CCDS

CCDS5724

HPRD

16038

IMGT

EMBL

GenPept

RNA Seq Atlas

5439