Version 5.4
Homo sapiens Gene: SMCR7
Summary
InnateDB Gene IDBG-33823.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMCR7
Gene Name Smith-Magenis syndrome chromosome region, candidate 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177427
Encoded Proteins
IDBP-33825
Smith-Magenis syndrome chromosome region, candidate 7
IDBP-239009
Smith-Magenis syndrome chromosome region, candidate 7
IDBP-239011
Smith-Magenis syndrome chromosome region, candidate 7
IDBP-239013
Smith-Magenis syndrome chromosome region, candidate 7
IDBP-764779
IDBP-761777
IDBP-761571
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:18260534-18266552
Strand Forward strand
Band p11.2
Transcripts
ENST00000323019 ENSP00000323591
ENST00000395706 ENSP00000379057
ENST00000395704 ENSP00000379056
ENST00000395703 ENSP00000379055
ENST00000579341 ENSP00000465801
ENST00000578621 ENSP00000464017
ENST00000578174 ENSP00000463015
ENST00000577216
ENST00000583745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007005 mitochondrion organization
GO:0032464 positive regulation of protein homooligomerization
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018599
View Gene Order
ENSBTAG00000017081
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655555
RefSeq NM_001144900 NM_139162 NM_148886
HUGO
OMIM
CCDS CCDS11193 CCDS45624 CCDS45625
HPRD 18074
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca