Version 5.4
Homo sapiens Protein: SMCR7
Summary
InnateDB Protein IDBP-33825.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMCR7
Protein Name Smith-Magenis syndrome chromosome region, candidate 7
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323591
InnateDB Gene IDBG-33823 (SMCR7)
Protein Structure
UniProt Annotation
Function Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity. {ECO:0000269PubMed:21508961, ECO:0000269PubMed:23283981, ECO:0000269PubMed:23530241, ECO:0000269PubMed:23921378}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000269PubMed:21508961}; Single-pass membrane protein {ECO:0000269PubMed:21508961}. Note=Colocalizes with DNM1L at mitochondrial membrane. Forms foci and rings around mitochondria.
Disease Associations
Tissue Specificity Expressed in all tissues tested with highest expression in heart and skeletal muscle. {ECO:0000269PubMed:11997338}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007005 mitochondrion organization
GO:0032464 positive regulation of protein homooligomerization
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96C03
PhosphoSite PhosphoSite-Q96C03
TrEMBL
UniProt Splice Variant
Entrez Gene 125170
UniGene Hs.655555
RefSeq NP_631901
HUGO HGNC:17920
OMIM 615498
CCDS CCDS11193
HPRD 18074
IMGT
EMBL AC127537 AF467443 AK056165 AK128310 BC014973 CH471196
GenPept AAH14973 AAL78340 BAB71108 BAC87377 EAW55651 EAW55652

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca