InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CASP6

Summary

InnateDB Gene

IDBG-33873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP6

Gene Name

caspase 6, apoptosis-related cysteine peptidase

Synonyms

MCH2

Species

Homo sapiens

Ensembl Gene

ENSG00000138794

Encoded Proteins

IDBP-33875

caspase 6, apoptosis-related cysteine peptidase

IDBP-33877

caspase 6, apoptosis-related cysteine peptidase

IDBP-484559

caspase 6, apoptosis-related cysteine peptidase

IDBP-480170

caspase 6, apoptosis-related cysteine peptidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21098228

CASP6 plays an important role in the activation of alveolar macrophages by neutrophils. The cleavage of IRAK3 by CASP6 mediates the degradation of NFKBIA and the induction of TNF upon stimulation by bacterial products.

Entrez Gene

Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:109688622-109703583

Strand

Reverse strand

Band

q25

Transcripts

ENST00000265164	ENSP00000265164
ENST00000352981	ENSP00000285333
ENST00000507550
ENST00000505117
ENST00000510324
ENST00000508203
ENST00000503684	ENSP00000427669
ENST00000505486	ENSP00000424080

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0042802	identical protein binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0030855	epithelial cell differentiation
GO:0045087	innate immune response (InnateDB)