Homo sapiens Gene: CASP6 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-33873.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | CASP6 | ||||||||||||||||||||||
Gene Name | caspase 6, apoptosis-related cysteine peptidase | ||||||||||||||||||||||
Synonyms | MCH2 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000138794 | ||||||||||||||||||||||
Encoded Proteins |
caspase 6, apoptosis-related cysteine peptidase
caspase 6, apoptosis-related cysteine peptidase
caspase 6, apoptosis-related cysteine peptidase
caspase 6, apoptosis-related cysteine peptidase
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
CASP6 plays an important role in the activation of alveolar macrophages by neutrophils. The cleavage of IRAK3 by CASP6 mediates the degradation of NFKBIA and the induction of TNF upon stimulation by bacterial products.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 4:109688622-109703583 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q25 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Caspase-mediated cleavage of cytoskeletal proteins pathway
Breakdown of the nuclear lamina pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Apoptosis pathway
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KEGG |
Apoptosis pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Caspase Cascade in Apoptosis
Direct p53 effectors
p75(NTR)-mediated signaling
C-MYB transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.654616 | ||||||||||||||||||||||
RefSeq | NM_001226 NM_032992 XM_005263271 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS3684 CCDS3685 | ||||||||||||||||||||||
HPRD | 03321 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||