InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP6

Summary

InnateDB Protein

IDBP-33877.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP6

Protein Name

caspase 6, apoptosis-related cysteine peptidase

Synonyms

MCH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000285333

InnateDB Gene

IDBG-33873 (CASP6)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0042802	identical protein binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0030855	epithelial cell differentiation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF00656

PRINTS

PR00376

PIRSF

SMART

SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt