InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GLRX

Summary

InnateDB Gene

IDBG-34038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRX

Gene Name

glutaredoxin (thioltransferase)

Synonyms

GRX; GRX1

Species

Homo sapiens

Ensembl Gene

ENSG00000173221

Encoded Proteins

IDBP-34040

glutaredoxin (thioltransferase)

IDBP-34042

glutaredoxin (thioltransferase)

IDBP-483721

glutaredoxin (thioltransferase)

IDBP-474908

glutaredoxin (thioltransferase)

IDBP-484865

glutaredoxin (thioltransferase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21078302

GLRX (GRX-1), a degluationylation enzyme, activates TRAF6 and is responsible for IL1R / TLR-dependent induction of NFkB pathway.

InnateDB Annotation from Orthologs

Summary

PMID 23159440

[Mus musculus] Glrx deficiency impairs neutrophil polarization, chemotaxis, adhesion, and phagocytosis.

Entrez Gene

Summary

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer\'s disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:95751319-95823005

Strand

Reverse strand

Band

q15

Transcripts

ENST00000379979	ENSP00000369314
ENST00000237858	ENSP00000237858
ENST00000508780	ENSP00000422708
ENST00000507605
ENST00000507412
ENST00000505427	ENSP00000427353
ENST00000512469	ENSP00000424636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0015038	glutathione disulfide oxidoreductase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045454	cell redox homeostasis
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000021591

View Gene Order

Pathways

NETPATH

REACTOME

REACT_21330

Synthesis and interconversion of nucleotide di- and triphosphates pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.28988 Hs.712696

RefSeq

NM_001118890 NM_001243658 NM_001243659 NM_002064

HUGO

OMIM

CCDS

CCDS4078

HPRD

02707

IMGT

EMBL

GenPept

RNA Seq Atlas