InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLRX

Summary

InnateDB Protein

IDBP-474908.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRX

Protein Name

glutaredoxin (thioltransferase)

Synonyms

GRX; GRX1;

Species

Homo sapiens

Ensembl Protein

ENSP00000427353

InnateDB Gene

IDBG-34038 (GLRX)

Protein Structure

UniProt Annotation

Function

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0015038	glutathione disulfide oxidoreductase activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0015949	nucleobase-containing small molecule interconversion
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045454	cell redox homeostasis
GO:0055086	nucleobase-containing small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002109 Glutaredoxin
IPR008554 Glutaredoxin-like
IPR011899 Glutaredoxin, eukaryotic/virial
IPR012336 Thioredoxin-like fold
IPR014025 Glutaredoxin subgroup

PFAM

PF00462
PF05768
PF13098
PF13192
PF13462
PF13905

PRINTS

PR00160

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35754