Version 5.4
Homo sapiens Gene: EGF
Summary
InnateDB Gene IDBG-34100.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EGF
Gene Name epidermal growth factor
Synonyms HOMG4; URG
Species Homo sapiens
Ensembl Gene ENSG00000138798
Encoded Proteins
IDBP-34102
epidermal growth factor
IDBP-481581
epidermal growth factor
IDBP-476156
epidermal growth factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:109912884-110012266
Strand Forward strand
Band q25
Transcripts
ENST00000265171 ENSP00000265171
ENST00000509793 ENSP00000424316
ENST00000503392 ENSP00000421384
ENST00000502723
ENST00000504633
ENST00000502579
ENST00000511228
ENST00000509996
ENST00000541061
ENST00000544918
ENST00000537316
ENST00000540840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
Biological Process
GO:0000186 activation of MAPKK activity
GO:0001525 angiogenesis
GO:0002576 platelet degranulation
GO:0006260 DNA replication
GO:0007165 signal transduction
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007262 STAT protein import into nucleus
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030168 platelet activation
GO:0035413 positive regulation of catenin import into nucleus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0043388 positive regulation of DNA binding
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0051048 negative regulation of secretion
GO:0060749 mammary gland alveolus development
GO:0070371 ERK1 and ERK2 cascade
GO:0090279 regulation of calcium ion import
GO:0090370 negative regulation of cholesterol efflux
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:2000008 regulation of protein localization to cell surface
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000028017
View Gene Order
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_318
Platelet degranulation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_12578
GAB1 signalosome pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04540
Gap junction pathway
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa05212
Pancreatic cancer pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
EGF signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
ceramide_pathway
Ceramide signaling pathway
txa2pathway
Thromboxane A2 receptor signaling
erbb1_internalization_pathway
Internalization of ErbB1
ptp1bpathway
Signaling events mediated by PTP1B
erbb1_downstream_pathway
ErbB1 downstream signaling
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
et_egfrpathway
EGFR-dependent Endothelin signaling events
tcptp_pathway
Signaling events mediated by TCPTP
erbb_network_pathway
ErbB receptor signaling network
shp2_pathway
SHP2 signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_pathway
Arf6 signaling events
telomerasepathway
Regulation of Telomerase
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.419815
RefSeq NM_001178130 NM_001178131 NM_001963 XM_005262799 XM_005262802
HUGO
OMIM
CCDS CCDS3689 CCDS54794 CCDS54795
HPRD 00578
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca