InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EGF

Summary

InnateDB Protein

IDBP-476156.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGF

Protein Name

epidermal growth factor

Synonyms

HOMG4; URG;

Species

Homo sapiens

Ensembl Protein

ENSP00000421384

InnateDB Gene

IDBG-34100 (EGF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity

Biological Process

GO:0001525	angiogenesis
GO:0002576	platelet degranulation
GO:0006260	DNA replication
GO:0007165	signal transduction
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007262	STAT protein import into nucleus
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0030168	platelet activation
GO:0035413	positive regulation of catenin import into nucleus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043388	positive regulation of DNA binding
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051048	negative regulation of secretion
GO:0070371	ERK1 and ERK2 cascade
GO:0090279	regulation of calcium ion import
GO:1900127	positive regulation of hyaluronan biosynthetic process
GO:2000008	regulation of protein localization to cell surface

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR016317 Pro-epidermal growth factor

PFAM

PF00058
PF00008
PF07645

PRINTS

PIRSF

PIRSF001778

SMART

SM00135
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt