Version 5.4
Homo sapiens Gene: PRPSAP2
Summary
InnateDB Gene IDBG-34360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRPSAP2
Gene Name phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms PAP41
Species Homo sapiens
Ensembl Gene ENSG00000141127
Encoded Proteins
IDBP-34362
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-239111
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372065
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372079
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372081
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372085
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372087
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372089
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372092
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-372097
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-761470
IDBP-763746
IDBP-760786
IDBP-591128
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-583879
phosphoribosyl pyrophosphate synthetase-associated protein 2
IDBP-763064
IDBP-758908
IDBP-762185
IDBP-762117
IDBP-759411
IDBP-757833
IDBP-760882
IDBP-761027
IDBP-808714
phosphoribosyl pyrophosphate synthetase-associated protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:18840085-18931287
Strand Forward strand
Band p11.2
Transcripts
ENST00000268835 ENSP00000268835
ENST00000395656 ENSP00000379017
ENST00000441887 ENSP00000395127
ENST00000414602 ENSP00000416964
ENST00000432893 ENSP00000399625
ENST00000455992 ENSP00000416021
ENST00000412418 ENSP00000402612
ENST00000419284 ENSP00000415446
ENST00000419071 ENSP00000392536
ENST00000422237 ENSP00000401144
ENST00000492129 ENSP00000459727
ENST00000487101 ENSP00000460584
ENST00000478622
ENST00000460724 ENSP00000461241
ENST00000466106
ENST00000542013 ENSP00000439129
ENST00000536323 ENSP00000443967
ENST00000574451 ENSP00000458301
ENST00000573253 ENSP00000459077
ENST00000570450 ENSP00000460967
ENST00000576355 ENSP00000458600
ENST00000575337
ENST00000573432
ENST00000574522 ENSP00000460138
ENST00000575228 ENSP00000460324
ENST00000575102 ENSP00000459441
ENST00000571907 ENSP00000461782
ENST00000610773 ENSP00000481322
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0004857 enzyme inhibitor activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0043086 negative regulation of catalytic activity
GO:0060348 bone development
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020528
View Gene Order
ENSBTAG00000014858
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.602507 Hs.632236
RefSeq NM_001243936 NM_001243940 NM_001243941 NM_001243942 NM_002767 XM_005256724 XM_005256725 XM_005256726 XM_005256727 XM_005256729
HUGO
OMIM
CCDS CCDS11200 CCDS58525 CCDS58526 CCDS58527
HPRD 04789
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca