Homo sapiens Gene: RNASEH2B
Summary
InnateDB Gene IDBG-34455.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol RNASEH2B
Gene Name ribonuclease H2, subunit B
Synonyms AGS2; DLEU8;
Species Homo sapiens
Ensembl Gene ENSG00000136104
Encoded Proteins
ribonuclease H2, subunit B
ribonuclease H2, subunit B
Protein Structure
Entrez Gene
Summary RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:51483814-51544592
Strand Forward strand
Band q14.3
Transcripts
ENST00000336617 ENSP00000337623
ENST00000422660 ENSP00000389877
ENST00000494721
ENST00000459983
ENST00000495244
ENST00000459681
ENST00000465541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q5TBB1
TrEMBL G3XAJ1
UniProt Splice Variant
Entrez Gene 79621
UniGene
RefSeq NM_001142279 NM_024570
HUGO 25671
OMIM 610326
CCDS CCDS45047 CCDS9425
HPRD
IMGT
EMBL AK021774 AK223340 AL137881 AY764036 BC001397 BC007332 BC010174 CH471075
GenPept AAH01397 AAH07332 AAH10174 AAX13343 BAB13892 BAD97060 CAI13913 EAX08864
ImmGen RNASEH2B (murine)
RNA Seq Atlas 79621