Homo sapiens Gene: RNASEH2B
Summary
InnateDB Gene IDBG-34455.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASEH2B
Gene Name ribonuclease H2, subunit B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136104
Encoded Proteins
ribonuclease H2, subunit B
ribonuclease H2, subunit B
ribonuclease H2, subunit B
ribonuclease H2, subunit B
Protein Structure
Entrez Gene
Summary RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:50909678-50973745
Strand Forward strand
Band q14.3
Transcripts
ENST00000336617 ENSP00000337623
ENST00000422660 ENSP00000389877
ENST00000495244
ENST00000459681
ENST00000465541
ENST00000613449
ENST00000621641
ENST00000616907 ENSP00000482701
ENST00000611510 ENSP00000481236
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006401 RNA catabolic process
GO:0009259 ribonucleotide metabolic process
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010629 negative regulation of gene expression
GO:0048146 positive regulation of fibroblast proliferation
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000001 regulation of DNA damage checkpoint
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
DNA replication pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q5TBB1
TrEMBL
UniProt Splice Variant
Entrez Gene 79621
UniGene
RefSeq NM_001142279 NM_024570 XM_006719867
HUGO HGNC:25671
OMIM 610326
CCDS CCDS45047 CCDS9425
HPRD
IMGT
EMBL AK021774 AK223340 AL137881 AY764036 BC001397 BC005088 BC007332 BC010174 CH471075
GenPept AAH01397 AAH05088 AAH07332 AAH10174 AAX13343 BAB13892 BAD97060 EAX08864
ImmGen RNASEH2B (murine)
RNA Seq Atlas 79621