Homo sapiens Gene: RNASEH2B

Summary
InnateDB Gene IDBG-34455.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol RNASEH2B
Gene Name ribonuclease H2, subunit B
Synonyms AGS2; DLEU8
Species Homo sapiens
Ensembl Gene ENSG00000136104
Encoded Proteins
IDBP-34457 ribonuclease H2, subunit B
IDBP-368659 ribonuclease H2, subunit B
Entrez Gene
Summary RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13: 51483814-51544592
Strand Forward strand
Band q14.3
Transcripts
ENST00000336617  ENSP00000337623
ENST00000422660  ENSP00000389877
ENST00000494721 
ENST00000459983 
ENST00000495244 
ENST00000459681 
ENST00000465541 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein‑Protein  8
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
Biological Process
GO:0006401 RNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0032299 ribonuclease H2 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000021932 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000020149 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa03030  DNA replication
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q5TBB1 
TrEMBL G3XAJ1
UniProt Splice Variant
Entrez Gene 79621 
UniGene
RefSeq NM_001142279  NM_024570 
HUGO 25671 
OMIM 610326
CCDS CCDS45047  CCDS9425 
HPRD
IMGT
EMBL AK021774 AK223340 AL137881 AY764036 BC001397 BC007332 BC010174 CH471075
GenPept AAH01397  AAH07332  AAH10174  AAX13343  BAB13892  BAD97060  CAI13913  EAX08864 
ImmGen RNASEH2B (murine) 
RNA Seq Atlas 79621