Version 5.4
Homo sapiens Gene: GRAP
Summary
InnateDB Gene IDBG-34497.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRAP
Gene Name GRB2-related adaptor protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000154016
Encoded Proteins
IDBP-34499
GRB2-related adaptor protein
IDBP-239162
GRB2-related adaptor protein
IDBP-763450
IDBP-762165
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:19020673-19047637
Strand Reverse strand
Band p11.2
Transcripts
ENST00000284154 ENSP00000284154
ENST00000395635 ENSP00000378997
ENST00000571380
ENST00000573099 ENSP00000459833
ENST00000583020 ENSP00000464328
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0007267 cell-cell signaling
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004837
View Gene Order
ENSBTAG00000003707
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL I3L2P9 K7EKU7
UniProt Splice Variant
Entrez Gene 10750
UniGene Hs.567416
RefSeq NM_006613
HUGO HGNC:4562
OMIM 604330
CCDS CCDS11202
HPRD 05062
IMGT
EMBL AC003957 AC007952
GenPept
RNA Seq Atlas 10750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca