Version 5.4
Homo sapiens Gene: NEUROG2
Summary
InnateDB Gene IDBG-34516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NEUROG2
Gene Name neurogenin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178403
Encoded Proteins
IDBP-34518
neurogenin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. The protein product of this gene also plays a role in the differentiation and survival of midbrain dopaminergic neurons. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:112513516-112516172
Strand Reverse strand
Band q25
Transcripts
ENST00000313341 ENSP00000317333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0001764 neuron migration
GO:0006351 transcription, DNA-templated
GO:0007411 axon guidance
GO:0021954 central nervous system neuron development
GO:0022008 neurogenesis
GO:0030182 neuron differentiation
GO:0030900 forebrain development
GO:0045165 cell fate commitment
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027967
View Gene Order
ENSBTAG00000015259
Not yet available
Cross-References
SwissProt Q9H2A3
TrEMBL
UniProt Splice Variant
Entrez Gene 63973
UniGene Hs.567563
RefSeq NM_024019
HUGO HGNC:13805
OMIM 606624
CCDS CCDS3698
HPRD
IMGT
EMBL AF303002 BC036847
GenPept AAG40770 AAH36847
RNA Seq Atlas 63973

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca