Version 5.4
Homo sapiens Gene: KRT75
Summary
InnateDB Gene IDBG-34519.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT75
Gene Name keratin 75
Synonyms K6HF; KB18; PFB
Species Homo sapiens
Ensembl Gene ENSG00000170454
Encoded Proteins
IDBP-34521
keratin 75
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52424070-52434525
Strand Reverse strand
Band q13.13
Transcripts
ENST00000252245 ENSP00000252245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022986
View Gene Order
ENSBTAG00000016121
Not yet available
Cross-References
SwissProt O95678
TrEMBL
UniProt Splice Variant
Entrez Gene 9119
UniGene Hs.697046
RefSeq NM_004693
HUGO HGNC:24431
OMIM 609025
CCDS CCDS8827
HPRD
IMGT
EMBL AC055736 AK298960 Y17282 Y19212
GenPept BAG61056 CAA76730 CAB76832
RNA Seq Atlas 9119

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca