Version 5.4
Homo sapiens Protein: KRT75
Summary
InnateDB Protein IDBP-34521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT75
Protein Name keratin 75
Synonyms K6HF; KB18; PFB;
Species Homo sapiens
Ensembl Protein ENSP00000252245
InnateDB Gene IDBG-34519 (KRT75)
Protein Structure
UniProt Annotation
Function Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
Subcellular Localization
Disease Associations Loose anagen hair syndrome (LAHS) [MIM:600628]: In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage. {ECO:0000269PubMed:11939812}. Note=The disease may be caused by mutations affecting the gene represented in this entry.
Tissue Specificity Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level). {ECO:0000269PubMed:14675170, ECO:0000269PubMed:15292489, ECO:0000269PubMed:18032949, ECO:0000269PubMed:9856802}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR003054 Keratin, type II
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01276
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95678
PhosphoSite PhosphoSite-O95678
TrEMBL
UniProt Splice Variant
Entrez Gene 9119
UniGene Hs.697046
RefSeq NP_004684
HUGO HGNC:24431
OMIM 609025
CCDS CCDS8827
HPRD 11057
IMGT
EMBL AC055736 AK298960 Y17282 Y19212
GenPept BAG61056 CAA76730 CAB76832

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca