Version 5.4
Homo sapiens Gene: EPN2
Summary
InnateDB Gene IDBG-34552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPN2
Gene Name epsin 2
Synonyms EHB21
Species Homo sapiens
Ensembl Gene ENSG00000072134
Encoded Proteins
IDBP-34554
epsin 2
IDBP-34556
epsin 2
IDBP-239168
epsin 2
IDBP-239170
epsin 2
IDBP-239174
epsin 2
IDBP-239176
epsin 2
IDBP-758080
IDBP-758672
IDBP-764185
IDBP-764829
IDBP-758315
IDBP-762142
IDBP-764569
IDBP-762697
IDBP-758333
IDBP-757824
IDBP-761493
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:19215615-19336715
Strand Forward strand
Band p11.2
Transcripts
ENST00000314728 ENSP00000320543
ENST00000347697 ENSP00000261495
ENST00000395628 ENSP00000378990
ENST00000395626 ENSP00000378988
ENST00000395620 ENSP00000378982
ENST00000395618 ENSP00000378980
ENST00000441293
ENST00000495155
ENST00000494192 ENSP00000460193
ENST00000572627
ENST00000580579 ENSP00000463769
ENST00000582015 ENSP00000462465
ENST00000584954
ENST00000584150 ENSP00000462606
ENST00000584633 ENSP00000462426
ENST00000585097
ENST00000571254 ENSP00000459542
ENST00000577692 ENSP00000463627
ENST00000575595 ENSP00000459678
ENST00000582969
ENST00000582659
ENST00000584707
ENST00000581024 ENSP00000462958
ENST00000583197 ENSP00000463141
ENST00000582234
ENST00000577195 ENSP00000462392
ENST00000577244
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005543 phospholipid binding
GO:0008289 lipid binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006897 endocytosis
GO:0007219 Notch signaling pathway
GO:0048568 embryonic organ development
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0030128 clathrin coat of endocytic vesicle
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001036
View Gene Order
ENSBTAG00000017771
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PBC1 J3KSA6 J3KSC7 J3KSF8 J3KTF6 J3QKL8 J3QLN2 J3QRG9 Q6NSL9
UniProt Splice Variant
Entrez Gene 22905
UniGene Hs.309467 Hs.669001 Hs.677375 Hs.733657 Hs.743618
RefSeq NM_001102664 NM_014964 NM_148921 XM_006721475 XM_006721476
HUGO HGNC:18639
OMIM 607263
CCDS CCDS11203 CCDS11204 CCDS42277
HPRD 06271
IMGT
EMBL AC106017 AC124066 BC070036
GenPept AAH70036
RNA Seq Atlas 100874309 22905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca