Version 5.4
Mus musculus Gene: Epn2
Summary
InnateDB Gene IDBG-183300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Epn2
Gene Name epsin 2
Synonyms 9530051D10Rik; AA536924; Ibp2
Species Mus musculus
Ensembl Gene ENSMUSG00000001036
Encoded Proteins
IDBP-183302
epsin 2
IDBP-263953
epsin 2
IDBP-263955
epsin 2
IDBP-263957
epsin 2
IDBP-536403
epsin 2
IDBP-540436
epsin 2
IDBP-535028
epsin 2
IDBP-532057
epsin 2
IDBP-718147
IDBP-716824
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072134:
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:61517249-61579687
Strand Reverse strand
Band B2
Transcripts
ENSMUST00000001063 ENSMUSP00000001063
ENSMUST00000108713 ENSMUSP00000104353
ENSMUST00000108712 ENSMUSP00000104352
ENSMUST00000108711 ENSMUSP00000104351
ENSMUST00000148956 ENSMUSP00000122514
ENSMUST00000153984 ENSMUSP00000122666
ENSMUST00000151545
ENSMUST00000147501 ENSMUSP00000117389
ENSMUST00000146455 ENSMUSP00000123675
ENSMUST00000141335
ENSMUST00000137525
ENSMUST00000178202 ENSMUSP00000136553
ENSMUST00000179936 ENSMUSP00000136950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005543 phospholipid binding
GO:0008289 lipid binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006897 endocytosis
GO:0007219 Notch signaling pathway
GO:0048568 embryonic organ development
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0030128 clathrin coat of endocytic vesicle
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000072134
View Gene Order
ENSBTAG00000017771
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.139695 Mm.398446 Mm.433685
RefSeq NM_001252188 NM_001252189 NM_010148 XM_006532171 XM_006532172
OMIM
CCDS CCDS24816 CCDS56779 CCDS56780
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca