Version 5.4
Homo sapiens Gene: AKAP8
Summary
InnateDB Gene IDBG-34589.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKAP8
Gene Name A kinase (PRKA) anchor protein 8
Synonyms AKAP 95; AKAP-8; AKAP-95; AKAP95
Species Homo sapiens
Ensembl Gene ENSG00000105127
Encoded Proteins
IDBP-34591
A kinase (PRKA) anchor protein 8
IDBP-762389
IDBP-760136
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15353385-15379798
Strand Reverse strand
Band p13.12
Transcripts
ENST00000269701 ENSP00000269701
ENST00000537303
ENST00000598597 ENSP00000469908
ENST00000595416
ENST00000599883 ENSP00000468902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0007076 mitotic chromosome condensation
GO:0007165 signal transduction
Cellular Component
GO:0000793 condensed chromosome
GO:0001939 female pronucleus
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016363 nuclear matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024045
View Gene Order
ENSBTAG00000001807
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QX51
UniProt Splice Variant
Entrez Gene 10270
UniGene Hs.743430
RefSeq NM_005858 XM_005259706
HUGO HGNC:378
OMIM 604692
CCDS CCDS12329
HPRD 05258
IMGT
EMBL AC005785 AC093060
GenPept
RNA Seq Atlas 10270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca