InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKAP8

Summary

InnateDB Protein

IDBP-34591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKAP8

Protein Name

A kinase (PRKA) anchor protein 8

Synonyms

AKAP 95; AKAP-8; AKAP-95; AKAP95;

Species

Homo sapiens

Ensembl Protein

ENSP00000269701

InnateDB Gene

IDBG-34589 (AKAP8)

Protein Structure

UniProt Annotation

Function

Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).

Subcellular Localization

Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.

Disease Associations

Tissue Specificity

Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0007076	mitotic chromosome condensation
GO:0007165	signal transduction

Cellular Component

GO:0000793	condensed chromosome
GO:0001939	female pronucleus
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016363	nuclear matrix