Homo sapiens Gene: CYP4F22

Summary
InnateDB Gene IDBG-34782.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol CYP4F22
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 22
Synonyms ARCI5; INLNE; LI3
Species Homo sapiens
Ensembl Gene ENSG00000171954
Encoded Proteins
IDBP-34784 cytochrome P450, family 4, subfamily F, polypeptide 22
IDBP-761774
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 15619304-15663127
Strand Forward strand
Band p13.12
Transcripts
ENST00000269703  ENSP00000269703
ENST00000601005  ENSP00000469866
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  1
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000061126 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000047933 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6NT55 
TrEMBL
UniProt Splice Variant
Entrez Gene 126410 
UniGene Hs.156452
RefSeq NM_173483 
HUGO 26820 
OMIM 611495
CCDS CCDS12331 
HPRD 08256
IMGT
EMBL AK096820 BC069351 BC093894 BC093896
GenPept AAH69351  AAH93894  AAH93896  BAC04868 
ImmGen CYP4F22 (murine) 
RNA Seq Atlas 126410