Homo sapiens Gene: CYP4F22
InnateDB Gene IDBG-34782.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol CYP4F22
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 22
Synonyms ARCI5; INLNE; LI3;
Species Homo sapiens
Ensembl Gene ENSG00000171954
Encoded Proteins
cytochrome P450, family 4, subfamily F, polypeptide 22
Protein Structure
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15619304-15663127
Strand Forward strand
Band p13.12
ENST00000269703 ENSP00000269703
ENST00000601005 ENSP00000469866
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Mus musculus
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
SwissProt Q6NT55
UniProt Splice Variant
Entrez Gene 126410
UniGene Hs.156452
RefSeq NM_173483
HUGO 26820
OMIM 611495
HPRD 08256
EMBL AK096820 BC069351 BC093894 BC093896
GenPept AAH69351 AAH93894 AAH93896 BAC04868
ImmGen CYP4F22 (murine)
RNA Seq Atlas 126410