Homo sapiens Gene: CYP4F22
Summary
InnateDB Gene IDBG-34782.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4F22
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 22
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171954
Encoded Proteins
cytochrome P450, family 4, subfamily F, polypeptide 22
Protein Structure
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15508493-15552317
Strand Forward strand
Band p13.12
Transcripts
ENST00000269703 ENSP00000269703
ENST00000601005 ENSP00000469866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Cytochrome P450 - arranged by substrate type pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Fatty acids pathway
Metabolism pathway
Biological oxidations pathway
Eicosanoids pathway
Miscellaneous substrates pathway
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6NT55
TrEMBL
UniProt Splice Variant
Entrez Gene 126410
UniGene Hs.156452
RefSeq NM_173483
HUGO HGNC:26820
OMIM 611495
CCDS CCDS12331
HPRD 08256
IMGT
EMBL AK096820 BC069351 BC093894 BC093896
GenPept AAH69351 AAH93894 AAH93896 BAC04868
ImmGen CYP4F22 (murine)
RNA Seq Atlas 126410