Version 5.4
Homo sapiens Gene: LDHC
Summary
InnateDB Gene IDBG-34918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDHC
Gene Name lactate dehydrogenase C
Synonyms CT32; LDH3; LDHX
Species Homo sapiens
Ensembl Gene ENSG00000166796
Encoded Proteins
IDBP-34920
lactate dehydrogenase C
IDBP-237967
lactate dehydrogenase C
IDBP-589716
lactate dehydrogenase C
IDBP-585465
lactate dehydrogenase C
IDBP-598586
lactate dehydrogenase C
IDBP-602095
lactate dehydrogenase C
IDBP-586087
lactate dehydrogenase C
IDBP-591542
lactate dehydrogenase C
IDBP-591773
lactate dehydrogenase C
IDBP-591094
lactate dehydrogenase C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5\' untranslated region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:18412307-18452058
Strand Forward strand
Band p15.1
Transcripts
ENST00000280704 ENSP00000280704
ENST00000396215 ENSP00000379518
ENST00000541669 ENSP00000437783
ENST00000545848 ENSP00000438196
ENST00000539369 ENSP00000441991
ENST00000546146 ENSP00000443414
ENST00000536880 ENSP00000439555
ENST00000537486 ENSP00000441478
ENST00000544105 ENSP00000439060
ENST00000535809 ENSP00000443997
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0019244 lactate biosynthetic process from pyruvate
GO:0019516 lactate oxidation
GO:0030317 sperm motility
GO:0044262 cellular carbohydrate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0031514 motile cilium
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030851
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pyruvate metabolism pathway
INOH website
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL F5H5G7
UniProt Splice Variant
Entrez Gene 3948
UniGene Hs.654377
RefSeq NM_002301 NM_017448 XM_005252918 XM_005252919
HUGO HGNC:6544
OMIM 150150
CCDS CCDS7840
HPRD 01027
IMGT
EMBL AC027544 AC084117
GenPept
RNA Seq Atlas 3948

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca