Version 5.4
Mus musculus Gene: Ldhc
Summary
InnateDB Gene IDBG-187010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldhc
Gene Name lactate dehydrogenase C
Synonyms Ldh-3; LDH-C4; Ldh-x; Ldh3; Ldhc4
Species Mus musculus
Ensembl Gene ENSMUSG00000030851
Encoded Proteins
IDBP-187012
lactate dehydrogenase C
IDBP-542787
lactate dehydrogenase C
IDBP-541099
lactate dehydrogenase C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166796:
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5\' untranslated region. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:46861203-46878142
Strand Forward strand
Band B3
Transcripts
ENSMUST00000014545 ENSMUSP00000014545
ENSMUST00000148565 ENSMUSP00000114206
ENSMUST00000126004 ENSMUSP00000115652
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0019244 lactate biosynthetic process from pyruvate
GO:0019516 lactate oxidation
GO:0030317 sperm motility
GO:0044262 cellular carbohydrate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0031514 motile cilium
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000166796
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu00010
Glycolysis / Gluconeogenesis pathway
mmu00640
Propanoate metabolism pathway
mmu00620
Pyruvate metabolism pathway
mmu00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Propanoate metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Pyruvate metabolism pathway
INOH website
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt P00342
TrEMBL D3YVR7 D3YZE4 Q548Z6
UniProt Splice Variant
Entrez Gene 16833
UniGene Mm.16563 Mm.467935
RefSeq NM_013580 XM_006540679 XM_006540680 XM_006540681
OMIM
CCDS CCDS21290
HPRD
IMGT
MGI ID MGI:96764
MGI Symbol Ldhc
EMBL AC090123 AF190799 AK007058 AK161399 BC049602 CH466603 M12781 M17587 X04752
GenPept AAA39425 AAA88315 AAG23522 AAH49602 BAB24844 BAE36375 CAA28449 EDL22948
RNA Seq Atlas 16833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca