Version 5.4
Homo sapiens Gene: TRIB1
Summary
InnateDB Gene IDBG-35403.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIB1
Gene Name tribbles homolog 1 (Drosophila)
Synonyms C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1
Species Homo sapiens
Ensembl Gene ENSG00000173334
Encoded Proteins
IDBP-35405
tribbles homolog 1 (Drosophila)
IDBP-477026
tribbles homolog 1 (Drosophila)
IDBP-478956
tribbles homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:125430321-125438405
Strand Forward strand
Band q24.13
Transcripts
ENST00000311922 ENSP00000312150
ENST00000520847 ENSP00000429063
ENST00000521778
ENST00000519576 ENSP00000428879
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0055106 ubiquitin-protein ligase regulator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007254 JNK cascade
GO:0014912 negative regulation of smooth muscle cell migration
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032496 response to lipopolysaccharide
GO:0043405 regulation of MAP kinase activity
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048662 negative regulation of smooth muscle cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032501
View Gene Order
ENSBTAG00000023179
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444947
RefSeq NM_001282985 NM_025195 XM_006716496 XM_006716497
HUGO
OMIM
CCDS CCDS6357 CCDS64971
HPRD 09863
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca