InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIB1

Summary

InnateDB Protein

IDBP-477026.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIB1

Protein Name

tribbles homolog 1 (Drosophila)

Synonyms

C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000429063

InnateDB Gene

IDBG-35403 (TRIB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0055106	ubiquitin-protein ligase regulator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007254	JNK cascade
GO:0014912	negative regulation of smooth muscle cell migration
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032496	response to lipopolysaccharide
GO:0043405	regulation of MAP kinase activity
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048662	negative regulation of smooth muscle cell proliferation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt