Version 5.4
Homo sapiens Gene: MRGPRX2
Summary
InnateDB Gene IDBG-35412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRGPRX2
Gene Name MAS-related GPR, member X2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183695
Encoded Proteins
IDBP-35414
MAS-related GPR, member X2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22069323
MRGPRX2 is a G protein-coupled receptor (GPCR) for the host defence peptide LL-37 in mast cells.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 11:19054455-19060681
Strand Reverse strand
Band p15.1
Transcripts
ENST00000329773 ENSP00000333800
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0042923 neuropeptide binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0019233 sensory perception of pain
GO:0030431 sleep
GO:0032467 positive regulation of cytokinesis
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q96LB1
TrEMBL W8W3L5
UniProt Splice Variant
Entrez Gene 117194
UniGene Hs.350566
RefSeq NM_054030
HUGO HGNC:17983
OMIM 607228
CCDS CCDS7847
HPRD
IMGT
EMBL AB065811 AB083626 AY042214 AY651130 AY651131 AY651132 AY651133 AY651134 AY651135 AY651136 AY651137 AY651138 AY651139 AY651140 AY651141 AY651142 AY651143 AY651144 AY651145 AY651146 AY651147 AY651148 AY651149 AY651150 AY651151 AY651152 AY651153 AY651154 AY651155 AY651156 AY651157 AY651158 AY651159 AY651160 AY651161 AY845175 AY845176 BC063450 CH471064 EU883579 HG426071
GenPept AAH63450 AAK91805 AAW70043 AAW70044 AAW70045 AAW70046 AAW70047 AAW70048 AAW70049 AAW70050 AAW70051 AAW70052 AAW70053 AAW70054 AAW70055 AAW70056 AAW70057 AAW70058 AAW70059 AAW70060 AAW70061 AAW70062 AAW70063 AAW70064 AAW70065 AAW70066 AAW70067 AAW70068 AAW70069 AAW70070 AAW70071 AAW70072 AAW70073 AAW70074 AAW70082 AAW70083 ACG60653 BAB89339 BAC06030 CDG86189 EAW68359
RNA Seq Atlas 117194

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca