InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MRGPRX2

Summary

InnateDB Protein

IDBP-35414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MRGPRX2

Protein Name

MAS-related GPR, member X2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333800

InnateDB Gene

IDBG-35412 (MRGPRX2)

Protein Structure

UniProt Annotation

Function

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin- stimulated cAMP levels, suggesting that this receptor is G(q)- coupled.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion. {ECO:0000269PubMed:12915402}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0042923	neuropeptide binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0019233	sensory perception of pain
GO:0030431	sleep
GO:0032467	positive regulation of cytokinesis
GO:0045087	innate immune response (InnateDB)