InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBA7

Summary

InnateDB Gene

IDBG-35493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA7

Gene Name

ubiquitin-like modifier activating enzyme 7

Synonyms

D8; UBA1B; UBE1L; UBE2

Species

Homo sapiens

Ensembl Gene

ENSG00000182179

Encoded Proteins

IDBP-35495

ubiquitin-like modifier activating enzyme 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:49805207-49813946

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000333486	ENSP00000333266
ENST00000497908
ENST00000488536
ENST00000483751
ENST00000478875
ENST00000473992
ENST00000489826
ENST00000460516
ENST00000460703
ENST00000478688
ENST00000494212

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0019782	ISG15 activating enzyme activity

Biological Process

GO:0006464	cellular protein modification process
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0019941	modification-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response