InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBA7

Summary

InnateDB Protein

IDBP-35495.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA7

Protein Name

ubiquitin-like modifier activating enzyme 7

Synonyms

D8; UBA1B; UBE1L; UBE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000333266

InnateDB Gene

IDBG-35493 (UBA7)

Protein Structure

UniProt Annotation

Function

Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269PubMed:16254333, ECO:0000269PubMed:20133869}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004839	ubiquitin activating enzyme activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0019782	ISG15 activating enzyme activity

Biological Process

GO:0006464	cellular protein modification process
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0019941	modification-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000011 Ubiquitin/SUMO-activating enzyme E1
IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR018075 Ubiquitin-activating enzyme, E1
IPR018965 Ubiquitin-activating enzyme e1, C-terminal
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF09358
PF10585

PRINTS

PR01849

PIRSF

SMART

SM00985

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt