Version 5.4
Homo sapiens Gene: CA7
Summary
InnateDB Gene IDBG-35664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA7
Gene Name carbonic anhydrase VII
Synonyms CAVII
Species Homo sapiens
Ensembl Gene ENSG00000168748
Encoded Proteins
IDBP-35666
carbonic anhydrase VII
IDBP-242355
carbonic anhydrase VII
IDBP-597038
carbonic anhydrase VII
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66844379-66854153
Strand Forward strand
Band q22.1
Transcripts
ENST00000338437 ENSP00000345659
ENST00000394069 ENSP00000377632
ENST00000548332 ENSP00000447178
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015701 bicarbonate transport
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0032849 positive regulation of cellular pH reduction
GO:0044281 small molecule metabolic process
GO:2001225 regulation of chloride transport
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031883
View Gene Order
ENSBTAG00000020889
Not yet available
Pathways
NETPATH
REACTOME
REACT_121123
Reversible hydration of carbon dioxide pathway
REACT_111217
Metabolism pathway
KEGG
hsa00910
Nitrogen metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P43166
TrEMBL
UniProt Splice Variant
Entrez Gene 766
UniGene Hs.37014
RefSeq NM_001014435 XM_005256136 XM_006721267 XM_006721268 NM_005182 XM_005256135
HUGO HGNC:1381
OMIM 114770
CCDS CCDS42173 CCDS10821
HPRD 00263
IMGT
EMBL AC004638 AC044802 AY075019 AY075020 BC033865 CH471092 M76420 M76421 M76422 M76423
GenPept AAA51923 AAC23785 AAH33865 AAL78167 AAL78168 EAW83047
RNA Seq Atlas 766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca