Version 5.4
Homo sapiens Gene: CDH16
Summary
InnateDB Gene IDBG-35695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH16
Gene Name cadherin 16, KSP-cadherin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166589
Encoded Proteins
IDBP-35697
cadherin 16, KSP-cadherin
IDBP-242367
cadherin 16, KSP-cadherin
IDBP-749910
IDBP-749231
IDBP-754491
IDBP-754071
IDBP-752297
IDBP-747027
IDBP-753755
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66908122-66918984
Strand Reverse strand
Band q22.1
Transcripts
ENST00000299752 ENSP00000299752
ENST00000394055 ENSP00000377619
ENST00000567269 ENSP00000455523
ENST00000565796 ENSP00000454784
ENST00000570262 ENSP00000456690
ENST00000568698 ENSP00000456891
ENST00000568632 ENSP00000455263
ENST00000567009 ENSP00000460891
ENST00000565235 ENSP00000463451
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0016339 calcium-dependent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031881
View Gene Order
ENSBTAG00000009585
Not yet available
Cross-References
SwissProt O75309
TrEMBL
UniProt Splice Variant
Entrez Gene 1014
UniGene Hs.513660
RefSeq NM_001204746 NM_001204744 NM_001204745 NM_004062 XM_005255768 XM_005255770
HUGO HGNC:1755
OMIM 603118
CCDS CCDS58472 CCDS10823 CCDS56002 CCDS58471
HPRD 11929
IMGT
EMBL AC009084 AF016272 AK225544 AK298255 AY358911 BC027912
GenPept AAC34255 AAH27912 AAQ89270 BAG60520
RNA Seq Atlas 1014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca