Version 5.4
Homo sapiens Gene: RNF31
Summary
InnateDB Gene IDBG-3579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF31
Gene Name ring finger protein 31
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000092098
Encoded Proteins
IDBP-3587
ring finger protein 31
IDBP-594859
ring finger protein 31
IDBP-596451
ring finger protein 31
IDBP-602588
ring finger protein 31
IDBP-603463
ring finger protein 31
IDBP-587656
ring finger protein 31
IDBP-603160
ring finger protein 31
IDBP-593005
ring finger protein 31
IDBP-598370
ring finger protein 31
IDBP-601414
ring finger protein 31
IDBP-595776
ring finger protein 31
IDBP-600452
ring finger protein 31
IDBP-585193
ring finger protein 31
IDBP-587179
ring finger protein 31
IDBP-601785
ring finger protein 31
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19136968
RNF31 complexes with RBCK1 (LUBAC) and is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of IKBKG.
Entrez Gene
Summary The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24146683-24160661
Strand Forward strand
Band q12
Transcripts
ENST00000324103 ENSP00000315112
ENST00000491351 ENSP00000453595
ENST00000483895 ENSP00000453672
ENST00000560875 ENSP00000454032
ENST00000559308 ENSP00000453471
ENST00000558634
ENST00000557878
ENST00000559533 ENSP00000454048
ENST00000557991 ENSP00000453423
ENST00000559438
ENST00000560071 ENSP00000453948
ENST00000559275 ENSP00000453574
ENST00000559882
ENST00000559260 ENSP00000453645
ENST00000560342
ENST00000558907 ENSP00000453601
ENST00000560787 ENSP00000452972
ENST00000559583
ENST00000559071
ENST00000560754 ENSP00000453501
ENST00000558452
ENST00000559449 ENSP00000454140
ENST00000559719 ENSP00000452820
ENST00000559491
ENST00000560631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 83 [view]
Protein-Protein 82 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0016567 protein ubiquitination
GO:0023035 CD40 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0097039 protein linear polyubiquitination
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0009898 cytoplasmic side of plasma membrane
GO:0035631 CD40 receptor complex
GO:0071797 LUBAC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047098
View Gene Order
ENSBTAG00000005815
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.375217
RefSeq NM_017999
HUGO
OMIM
CCDS CCDS41931
HPRD 11516
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca