Version 5.4
Homo sapiens Gene: CES2
Summary
InnateDB Gene IDBG-35809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES2
Gene Name carboxylesterase 2
Synonyms CE-2; CES2A1; iCE; PCE-2
Species Homo sapiens
Ensembl Gene ENSG00000172831
Encoded Proteins
IDBP-35811
carboxylesterase 2
IDBP-378782
carboxylesterase 2
IDBP-748049
IDBP-753780
IDBP-752971
IDBP-748228
IDBP-746457
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66934444-66945096
Strand Forward strand
Band q22.1
Transcripts
ENST00000317091 ENSP00000317842
ENST00000417689 ENSP00000394452
ENST00000566182 ENSP00000463166
ENST00000563988
ENST00000568470 ENSP00000456167
ENST00000566359
ENST00000564420 ENSP00000464620
ENST00000561843
ENST00000570032 ENSP00000457721
ENST00000561697 ENSP00000463641
ENST00000567128
ENST00000568347
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0047374 methylumbelliferyl-acetate deacetylase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0009056 catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8824
UniGene Hs.282975 Hs.569560 Hs.706454
RefSeq NM_003869 NM_198061
HUGO HGNC:1864
OMIM 605278
CCDS CCDS10825 CCDS45507
HPRD 07062
IMGT
EMBL
GenPept
RNA Seq Atlas 8824

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca