InnateDB Gene
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IDBG-35809.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CES2
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Gene Name
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carboxylesterase 2
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Synonyms
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CE-2; CES2A1; iCE; PCE-2
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000172831
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
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Type |
Protein coding
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Genomic Location
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Chromosome 16:66934444-66945096
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Strand
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Forward strand
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Band
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q22.1
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
0
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016787
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hydrolase activity
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GO:0047374
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methylumbelliferyl-acetate deacetylase activity
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GO:0052689
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carboxylic ester hydrolase activity
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
NETPATH |
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REACTOME |
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KEGG |
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INOH |
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PID NCI |
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SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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8824
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UniGene
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Hs.282975
Hs.569560
Hs.706454
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RefSeq
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NM_003869
NM_198061
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HUGO
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HGNC:1864
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OMIM
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605278
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CCDS
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CCDS10825
CCDS45507
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HPRD |
07062
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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8824
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