Version 5.4
Homo sapiens Protein: CES2
Summary
InnateDB Protein IDBP-35811.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES2
Protein Name carboxylesterase 2
Synonyms CE-2; CES2A1; iCE; PCE-2;
Species Homo sapiens
Ensembl Protein ENSP00000317842
InnateDB Gene IDBG-35809 (CES2)
Protein Structure
UniProt Annotation
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. {ECO:0000269PubMed:9169443}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000250}.
Disease Associations
Tissue Specificity Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum. {ECO:0000269PubMed:9144407}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0047374 methylumbelliferyl-acetate deacetylase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0009056 catabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Protein Structure and Domains
PDB ID
InterPro IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00135
PF07859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00748
PhosphoSite PhosphoSite-O00748
TrEMBL J3QLP1
UniProt Splice Variant
Entrez Gene 8824
UniGene Hs.706454
RefSeq NP_003860
HUGO HGNC:1864
OMIM 605278
CCDS CCDS10825
HPRD 07062
IMGT
EMBL AC009084 AK290482 AL713761 AY851164 BC032095 BX538086 CH471092 D50579 U60553 Y09616
GenPept AAB03611 AAH32095 AAW29943 BAA23606 BAF83171 CAA70831 CAD28531 CAD98009 EAW83058 EAW83059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca