Version 5.4
Homo sapiens Gene: CES3
Summary
InnateDB Gene IDBG-35844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES3
Gene Name carboxylesterase 3
Synonyms ES31
Species Homo sapiens
Ensembl Gene ENSG00000172828
Encoded Proteins
IDBP-35846
carboxylesterase 3
IDBP-242398
carboxylesterase 3
IDBP-600760
carboxylesterase 3
IDBP-749304
IDBP-754191
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66961237-66975148
Strand Forward strand
Band q22.1
Transcripts
ENST00000303334 ENSP00000304782
ENST00000394037 ENSP00000377602
ENST00000543856 ENSP00000445559
ENST00000566746
ENST00000566453 ENSP00000456203
ENST00000570236 ENSP00000457547
ENST00000568118
ENST00000564715
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL H3BUA3
UniProt Splice Variant
Entrez Gene 23491
UniGene Hs.268700
RefSeq NM_001185176 NM_001185177 NM_024922
HUGO HGNC:1865
OMIM 605279
CCDS CCDS10826 CCDS54022 CCDS54023
HPRD 07014
IMGT
EMBL AC009084
GenPept
RNA Seq Atlas 23491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca