Version 5.4
Homo sapiens Protein: CES3
Summary
InnateDB Protein IDBP-35846.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES3
Protein Name carboxylesterase 3
Synonyms ES31;
Species Homo sapiens
Ensembl Protein ENSP00000304782
InnateDB Gene IDBG-35844 (CES3)
Protein Structure
UniProt Annotation
Function Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in liver, colon and small intestine. {ECO:0000269PubMed:14581373, ECO:0000269PubMed:15100172, ECO:0000269PubMed:15687373}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005788 endoplasmic reticulum lumen
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00135
PF07859
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UWW8
PhosphoSite PhosphoSite-Q6UWW8
TrEMBL
UniProt Splice Variant
Entrez Gene 23491
UniGene Hs.268700
RefSeq NP_079198
HUGO HGNC:1865
OMIM 605279
CCDS CCDS10826
HPRD 07014
IMGT
EMBL AC009084 AK025389 AY358609 BC053670 CH471092 EU595874
GenPept AAH53670 AAQ88972 ACD11491 BAB15123 EAW83060

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca