Version 5.4
Homo sapiens Gene: NELL1
Summary
InnateDB Gene IDBG-35988.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NELL1
Gene Name NEL-like 1 (chicken)
Synonyms IDH3GL; NRP1
Species Homo sapiens
Ensembl Gene ENSG00000165973
Encoded Proteins
IDBP-35990
NEL-like 1 (chicken)
IDBP-35992
NEL-like 1 (chicken)
IDBP-35994
NEL-like 1 (chicken)
IDBP-599647
NEL-like 1 (chicken)
IDBP-809151
NEL-like 1 (chicken)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:20669551-21575681
Strand Forward strand
Band p15.1
Transcripts
ENST00000298925 ENSP00000298925
ENST00000357134 ENSP00000349654
ENST00000325319 ENSP00000317837
ENST00000532434 ENSP00000437170
ENST00000528046
ENST00000527873
ENST00000529595
ENST00000524738
ENST00000528495
ENST00000530672
ENST00000529218
ENST00000534263
ENST00000619031 ENSP00000479479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0030501 positive regulation of bone mineralization
GO:0033689 negative regulation of osteoblast proliferation
GO:0045669 positive regulation of osteoblast differentiation
GO:2000599 negative regulation of cyclin catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000055409
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.657172
RefSeq NM_001288713 NM_001288714 NM_006157 NM_201551
HUGO
OMIM
CCDS CCDS44555 CCDS73267 CCDS73268 CCDS7855
HPRD 09081
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca