InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NELL1

Summary

InnateDB Protein

IDBP-35992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NELL1

Protein Name

NEL-like 1 (chicken)

Synonyms

IDH3GL; NRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000349654

InnateDB Gene

IDBG-35988 (NELL1)

Protein Structure

UniProt Annotation

Function

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. {ECO:0000269PubMed:21723284}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21723284}. Nucleus envelope {ECO:0000269PubMed:21723284}. Secreted {ECO:0000250}. Note=Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007399	nervous system development
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0030501	positive regulation of bone mineralization
GO:0033689	negative regulation of osteoblast proliferation
GO:0045669	positive regulation of osteoblast differentiation
GO:2000599	negative regulation of cyclin catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001007 von Willebrand factor, type C
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR006552 VWC out
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00093
PF00054
PF02210
PF07645

PRINTS

PIRSF

SMART

SM00181
SM00214
SM00210
SM00282
SM00179
SM00215

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92832