InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYO9B

Summary

InnateDB Gene

IDBG-36042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO9B

Gene Name

myosin IXB

Synonyms

CELIAC4; MYR5

Species

Homo sapiens

Ensembl Gene

ENSG00000099331

Encoded Proteins

IDBP-235668

myosin IXB

IDBP-762947

IDBP-764118

IDBP-765379

IDBP-762083

IDBP-765336

IDBP-766134

IDBP-765640

IDBP-766285

IDBP-761415

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:17075781-17214537

Strand

Forward strand

Band

p13.11

Transcripts

ENST00000397274	ENSP00000380444
ENST00000597572
ENST00000598101
ENST00000601749
ENST00000598419	ENSP00000472296
ENST00000593533
ENST00000598464
ENST00000599420
ENST00000593411
ENST00000596942	ENSP00000472964
ENST00000601490
ENST00000595641	ENSP00000472915
ENST00000602177	ENSP00000472611
ENST00000602158	ENSP00000469437
ENST00000595618	ENSP00000471457
ENST00000597881
ENST00000597073	ENSP00000469289
ENST00000594824	ENSP00000471367
ENST00000594971	ENSP00000470849

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005096	GTPase activator activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity
GO:0043008	ATP-dependent protein binding
GO:0043531	ADP binding
GO:0046872	metal ion binding
GO:0051015	actin filament binding

Biological Process

GO:0002548	monocyte chemotaxis
GO:0006200	ATP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0008152	metabolic process
GO:0030010	establishment of cell polarity
GO:0030048	actin filament-based movement
GO:0032321	positive regulation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0048246	macrophage chemotaxis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0072673	lamellipodium morphogenesis

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016459	myosin complex
GO:0030027	lamellipodium
GO:0031941	filamentous actin
GO:0032433	filopodium tip
GO:0048471	perinuclear region of cytoplasm